725 — Clinically relevant pharmacokinetic knowledge on antibiotic dosing (part 3 of 3)
Highlights
- Slash episode four, one, six
Summary:
This is part three of a three part series that began with episode 414. The survey was published may two thousand 19 in the journal critical care, titled clinically relevant pharmaco conectic knowledge on antobiatic dosing among intensive care professionals is insufficient. Questions nine, ten, 11 and 12 tie back into understanding drivers behind drug half life and how they can change in critical illness.
Transcript:
Speaker 1
What's up, pharmacy nation. I'm pharmacy joe. Thank you for listening to the elective rotation, a critical care pharmacy podcast. This is episode 416. In this episode, i'll discuss the final four questions of a recent survey of intensive care professionals about clinically relevant farm cononic knowledge on antibiotic dosing. This is part three of a three part series that began with episode 414. I have all the evidence supporting today show linked up in the show notes at pharmacy jo dot com. Slash episode four, one, six. The survey was published may two thousand 19 in the journal critical care, titled clinically relevant pharmaco conectic knowledge on antobiatic dosing among intensive care professionals is insufficient. This was a cross sectional study, an the lead author was lucas m florin. Questions nine, ten, 11 and 12 of the survey all tie back into understanding drivers behind drug half life and how they can change in critical illness. Question nine lists volume of distribution and clearance, and asks, how do these perimeters change in the initial phase of septic shock, following adequate volume resuscitation, both volume of distribution and clearance increase in septic shock following resuscitation, volume of distribution increases because the added fluids add to the theoretical compartment that medications distribute into. (Time 0:00:38)
- Slash episode four, one, six
Summary:
This is part three of a three part series that began with episode 414. The survey was published may two thousand 19 in the journal critical care, titled clinically relevant pharmaco conectic knowledge on antobiatic dosing among intensive care professionals is insufficient. Questions nine, ten, 11 and 12 tie back into understanding drivers behind drug half life and how they can change in critical illness.
Transcript:
Speaker 1
What's up, pharmacy nation. I'm pharmacy joe. Thank you for listening to the elective rotation, a critical care pharmacy podcast. This is episode 416. In this episode, i'll discuss the final four questions of a recent survey of intensive care professionals about clinically relevant farm cononic knowledge on antibiotic dosing. This is part three of a three part series that began with episode 414. I have all the evidence supporting today show linked up in the show notes at pharmacy jo dot com. Slash episode four, one, six. The survey was published may two thousand 19 in the journal critical care, titled clinically relevant pharmaco conectic knowledge on antobiatic dosing among intensive care professionals is insufficient. This was a cross sectional study, an the lead author was lucas m florin. Questions nine, ten, 11 and 12 of the survey all tie back into understanding drivers behind drug half life and how they can change in critical illness. Question nine lists volume of distribution and clearance, and asks, how do these perimeters change in the initial phase of septic shock, following adequate volume resuscitation, both volume of distribution and clearance increase in septic shock following resuscitation, volume of distribution increases because the added fluids add to the theoretical compartment that medications distribute into. Clearance increases because resuscitation restores adequate stroke volume and blood flow to vital organs such as the liver and kidney. (Time 0:00:38)